Serum and urethral antibody response in Mycoplasma genitalium-infected men.

The antibody response to Mycoplasma genitalium in serum and urethral secretions of men with non-gonococcal urethritis was examined longitudinally. Serum and urethral antibodies reacted primarily with the MgpB and MgpC adhesins. Serum antibodies persisted throughout follow-up while urethral antibodies waned despite organism persistence. Declining antibodies may facilitate chronic infection.