Docosahexaenoic Acid Alleviates Trimethylamine- N -oxide-mediated Impairment of Neovascularization in Human Endothelial Progenitor Cells.
Nutrients(2023)
Abstract
TMAO could significantly inhibit SCF-mediated neovascularization, in part in association with an upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK cascades, suppression of γ-GCS protein, and decreased levels of GSH and GSH/GSSG ratio. Furthermore, the DHA could alleviate the detrimental effects of TMAO and induce neovasculogenesis through suppression of miR-221 level, activation of Akt/eNOS and MAPK/ERK signaling cascades, increased expression of γ-GCS protein, and increment of cellular GSH level and GSH/GSSG ratio in hEPCs.
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Key words
neovascularization,trimethylamine-n-oxide-mediated
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