Production improvement of FK506 in Streptomyces tsukubaensis by metabolic engineering strategy.

Journal of applied microbiology(2023)

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摘要
Methylmalonyl-CoA might be the key rate-limiting factors in FK506 biosynthesis and overexpression of the gene PCCB1 and further addition of isoleucine and valine could increase the yield of FK506 by 56.6%.
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关键词
FK506, metabolomics, metabolic engineering, feeding strategies
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