Production improvement of FK506 in Streptomyces tsukubaensis by metabolic engineering strategy.

Hai-Tao Chen,Xiao-Ying Zhang,Qing-Bin Wu,Qing-Wei Zhao,Xin-Ai Chen,Yong-Quan Li

Journal of applied microbiology（2023）

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摘要

Methylmalonyl-CoA might be the key rate-limiting factors in FK506 biosynthesis and overexpression of the gene PCCB1 and further addition of isoleucine and valine could increase the yield of FK506 by 56.6%.

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关键词

FK506, metabolomics, metabolic engineering, feeding strategies

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