Enhanced inflammasome-mediated inflammation and impaired autophagy in peripheral blood mononuclear cells is associated with non-alcoholic fatty liver disease severity.

Samrat Saha,Sujay Ray,Arpan Mandal,Ujjal Das,Tuhin Bhattacharya,Zofa Shireen, Sankalita Sarkar,Rakhi Dey Sharma,Saurabh Ghosh,Sanjit Dey

Life sciences（2023）

Cited 0|Views6

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Abstract

Present data provide mechanistic evidence of impaired autophagy and intracellular ROS triggering inflammasome activation in PBMCs which could potentially exacerbate NAFLD severity.

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Key words

impaired autophagy,inflammation,liver disease,peripheral blood mononuclear cells,inflammasome-mediated,non-alcoholic

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