Deficiency in the production of antibodies to lipids correlates with increased lipid metabolism in severe COVID-19 patients.

Ignacio Piédrola, Sara Martínez,Ana Gradillas,Alma Villaseñor,Vanesa Alonso-Herranz,Isabel Sánchez-Vera,Esther Escudero,Isabel A Martín-Antoniano,Jose Felipe Varona, Andrés Ruiz,Jose María Castellano,Úrsula Muñoz,María C Sádaba

Frontiers in immunology（2023）

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摘要

Antibodies to lipids are essential for defense against SARS-CoV-2. Patients with low levels of anti-lipid antibodies have an elevated inflammatory response mediated by lysoglycerophospholipids. These findings provide novel prognostic biomarkers and therapeutic targets.

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关键词

natural antibodies, COVID-19, IgM, inflammation, lipidomic, lysophosphatidylcholine, lysophosphatidylethanolamine, phosphatidylinositol

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