Severe Descemetocele after EDTA Chelation for Band Keratopathy

A 62-year-old man presented with bilateral band keratopathy (A, anterior segment [AS] photography; B, AS-OCT) with no other relevant systemic or ocular findings. The patient was treated with topical ethylenediaminetetraacetic acid (EDTA) 2% twice daily bilaterally. The patient reported acute vision loss in his left eye 20 days later. He showed a severe descemetocele with surrounding stromal melting and anterior chamber inflammatory response (C, AS photography; D, AS-OCT). His right eye showed no significant changes. The following week, the patient required an urgent penetrating keratoplasty due to corneal perforation (Magnified version of Figure A-D is available online at www.aaojournal.org).