Temporal trends of breast cancer burden in the Western Pacific Region from 1990 to 2044: Implications from the Global Burden of Disease Study 2019

Introduction: Breast cancer (BC) is a malignant disease that occurs worldwide and poses serious health burden. Objectives: To assess the prevalence of BC burden in the Western Pacific region (WPR) from 1990 to 2019, and to predict trends from 2020 to 2044. To analyze the driving factors and put forward the regionoriented improvement. Methods: Based on the Global Burden of Disease Study 2019, BC cases, deaths, disability -adjusted life years (DALYs) cases, age -standardized incidence rate (ASIR), age -standardized death rate (ASDR), and age -standardized DALYs rate in WPR from 1990 to 2019 was obtained and analysed. Age -periodcohort (APC) model was used to analyze age, period, and cohort effects in BC, and Bayesian APC (BAPC) was used to predict trends over the next 25 years. Results: In conclusion, BC incidence and deaths in the WPR have increased rapidly over the past 30 years and are expected to continue to increase between 2020 and 2044. Among behavioral and metabolic fac- tors, high body -mass index was the main risk factor for BC mortality in middle -income countries, whereas alcohol use was the main risk factor in Japan. Age is a key factor in the development of BC, with 40 years being the critical point. Incidence trends coincide with the course of economic development. Conclusions: The BC burden remains an essential public health issue in the WPR and will increase sub- stantially in the future. More efforts should be made in middle -income countries to prompt the health behavior and minimize the burden of BC because these nations accounts for the majority of BC burden in the WPR. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).