Fusion-driven Spindle Cell Rhabdomyosarcomas of Bone and Soft Tissue: A Clinicopathologic and Molecular Genetic Study of 25 Cases

Carina A. Dehner,Stephen M. Broski,Jeanne M. Meis,Paari Murugan,John S.A. Chrisinger,Carlos Sosa,Matthew Petersen,Kevin C. Halling,Sounak Gupta,Andrew L. Folpe

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc（2023）

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摘要

The evolving classification of rhabdomyosarcoma (RMS) now includes spindle cell RMS (SRMS). Bone/soft tissue SRMS often harbor TFCP2, or less often MEIS1 rearrangements. We studied 25 fusion-driven SRMS involving bone (n = 19) and soft tissue (n = 6).

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bone tumors,immunohistochemistry,molecular genetics,soft tissue tumors,rhabdomyosarcoma

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