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Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation.

Roland Hjerpe,Thimo Kurz

Molecular cell（2023）

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Abstract
Most methods for targeted protein degradation (TPD) deliver targets to E3 ubiquitin ligases, leading to proteasomal degradation. In this issue of Molecular Cell, Shaaban et al.1 illuminate cullin-RING ubiquitin ligase (CRL) modulation by CAND1, which can be utilized for TPD.
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