Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation.
Molecular cell(2023)
Abstract
Most methods for targeted protein degradation (TPD) deliver targets to E3 ubiquitin ligases, leading to proteasomal degradation. In this issue of Molecular Cell, Shaaban et al.1 illuminate cullin-RING ubiquitin ligase (CRL) modulation by CAND1, which can be utilized for TPD.
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