Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression.

Jing Yu, Wen-Zhao Yan,Xin-Hua Zhang,Bin Zheng,Wen-Sen Pan,Zhan Yang,Hong Zhang,Zi-Yuan Nie,Ying Ma,Yang Bai,Long Zhang,Dan-Dan Feng,Jin-Kun Wen

Journal of geriatric cardiology : JGC（2023）

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摘要

CircZBTB46 was identified as a novel inhibitor of COL1 synthesis in VSMCs, highlighting the importance of circZBTB46 and PDLIM5 in regulating TGF-beta/Smad signaling and COL1A2 expression.

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关键词

smad,collagen,circzbtb46,signaling,down-regulation

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