Farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis.

Xinzhu Liu,Jiaxuan Wang, Maogang Li,Jiannan Qiu,Xingying Li,Li Qi,Jia Liu,Ping Liu,Guoxiang Xie,Xiaoning Wang

Journal of gastroenterology and hepatology（2023）

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摘要

All the results suggested that FXR plays a key role in both FA and BA metabolism in NAFLD combined with cholestasis and thus may be a potential target for the treatment of disorders of BA and FA metabolism in NAFLD combined with cholestasis.

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关键词

Alpha-naphthylisothiocyanate, Bile acid, Cholestasis, Farnesoid X receptor, Fatty acid, Nonalcoholic fatty liver disease

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