Effectiveness of multiple disease-modifying therapies in relapsing-remitting multiple sclerosis: causal inference to emulate a multiarm randomised trial.

Ibrahima Diouf,Charles B Malpas,Sifat Sharmin,Izanne Roos,Dana Horakova,Eva Kubala Havrdova,Francesco Patti,Vahid Shaygannejad,Serkan Ozakbas,Sara Eichau,Marco Onofrj,Alessandra Lugaresi,Raed Alroughani,Alexandre Prat,Pierre Duquette,Murat Terzi,Cavit Boz,Francois Grand'Maison,Patrizia Sola,Diana Ferraro,Pierre Grammond,Bassem Yamout,Ayse Altintas,Oliver Gerlach,Jeannette Lechner-Scott,Roberto Bergamaschi,Rana Karabudak,Gerardo Iuliano,Christopher McGuigan,Elisabetta Cartechini,Stella Hughes,Maria Jose Sa,Claudio Solaro,Ludwig Kappos,Suzanne Hodgkinson,Mark Slee,Franco Granella,Koen de Gans,Pamela A McCombe,Radek Ampapa,Anneke van der Walt,Helmut Butzkueven,José Luis Sánchez-Menoyo,Steve Vucic,Guy Laureys,Youssef Sidhom,Riadh Gouider,Tamara Castillo-Trivino,Orla Gray,Eduardo Aguera-Morales,Abdullah Al-Asmi,Cameron Shaw,Talal M Al-Harbi,Tunde Csepany,Angel P Sempere, Irene Treviño Frenk,Elizabeth A Stuart,Tomas Kalincik

Journal of neurology, neurosurgery, and psychiatry（2023）

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摘要

The effectiveness of natalizumab and fingolimod in active RRMS is superior to dimethyl fumarate, teriflunomide, glatiramer acetate and interferon beta. This study demonstrates the utility of MSM in emulating trials to compare clinical effectiveness among multiple interventions simultaneously.

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MULTIPLE SCLEROSIS, STATISTICS

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