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The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment.

Daniela Barone,Carmelina Antonella Iannuzzi,Iris Maria Forte, Maria Carmen Ragosta,Maria Cuomo,Milena Dell'Aquila,Angela Altieri,Antonella Caporaso,Rosa Camerlingo,Maria Manuela Rigano,Daria Maria Monti,Amalia Barone,Paola Imbimbo,Luigi Frusciante,Marcellino Monda,Margherita D'Angelo,Michelino De Laurentiis,Antonio Giordano,Luigi Alfano

Frontiers in oncology（2023）

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Abstract
We described the potential role of DHO extract in the modulation of DNA repair, in response to Camptothecin treatment (CPT), favoring an increased sensitivity of HeLa cell lines to topoisomerase inhibitor therapy.
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Key words
DNA damage response, Solanum lycopersicum, homologous recombination, DNA repair, single strand annealing
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