The hydrophilic extract from a new tomato genotype (named DHO) kills cancer cell lines through the modulation of the DNA damage response induced by Campthotecin treatment.
Frontiers in oncology(2023)
摘要
We described the potential role of DHO extract in the modulation of DNA repair, in response to Camptothecin treatment (CPT), favoring an increased sensitivity of HeLa cell lines to topoisomerase inhibitor therapy.
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关键词
DNA damage response, Solanum lycopersicum, homologous recombination, DNA repair, single strand annealing
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