Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin.

Yu Yan,Guorong Yan,Zhi Cao,Bo Wang,Qingyu Zeng, Lei Shi,Qihang Chang,Chengqian Chen,Linglin Zhang,Caihe Liao,Shengkai Jin,Xiaofei Sun,Guolong Zhang,Peiru Wang,Xiuli Wang

Frontiers in immunology（2023）

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摘要

ALA-PDT has potential to rejuvenate immune cells, partially reversed immunosenescence and improved the immunosuppressive state, ultimately remodelling the immune microenvironment in photoaged skin. These results provide an important immunological basis for further exploring strategies to reverse skin photoaging, chronological aging and potentially systemic aging.

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关键词

ALA-PDT, single cell RNA sequencing (scRNA-seq), photoaging, immune microenvironment, immunosenescence

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