Heparin Prowess: Favorable Vascular-Immune Reprogramming in Pancreatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research(2023)
摘要
Several approaches for overcoming immunotherapy resistance in pancreatic and colorectal cancer syngeneic models were assessed using heparin and immunotherapy. Beneficial responses were attributed to heparin-induced vascular normalization, ensuing CD8+ T-cell infiltration, and M1 macrophage polarization, suggesting the potential for heparin-anchored therapies in cold tumors such as pancreatic cancer. See related article by Wei et al., p. 2525.
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