BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway.

Pingping Xiao,Xuyan Chen,Zhigao Dong,Wei Fan,Yongquan Chen,Junnan Su,Qingqing Wang,Lili Ma

Hematology (Amsterdam, Netherlands)（2023）

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摘要

BNIP3 overexpression induced apoptosis in myeloma cells and increased myeloma cell sensitivity to BTZ. These effects may be mediated by the ROS/p38 MAPK signaling pathway.

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关键词

myeloma cell apoptosis,bnip3 overexpression,bortezomib,mapk pathway

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