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Sex-dependent association of DNA methylation in the coding region of the corticotropin-releasing hormone gene and schizophrenia spectrum disorder.

Lili Qing,Peng Xiong,Yumei Lu, Hongyan Jiang,Shengjie Nie

Annals of human biology（2023）

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Abstract
Differences in methylation were detectable in the peripheral blood of patients with SSD. Epigenetic abnormalities in the gene were closely related to positive symptoms of SSD, suggesting that epigenetic processes may mediate the pathophysiology of SSD.
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Key words
Schizophrenia spectrum disorder, HPA axis, CRH, DNA methylation
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