Impact of radiation on host immune system in patients treated with chemoradiotherapy and durvalumab consolidation for unresectable locally advanced non-small cell lung cancer.

Corentin Pasquier,Léonor Chaltiel,Carole Massabeau,Audrey Rabeau,Louisiane Lebas,Amélie Lusque,Jean-Sébastien Texier,Elizabeth Cohen-Jonathan Moyal,Julien Mazières,Jonathan Khalifa

Frontiers in oncology（2023）

Cited 5|Views9

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Abstract

The inclusion of at least one NITDLN station within the CTV was an independent factor for poorer PFS in the context of CCRT and durvalumab for LA-NSCLC. The optimal sparing of immune structures might help in achieving better synergy between radiotherapy and immunotherapy in this indication.

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Key words

radiotherapy,immunotherapy,non-small cell lung cancer (NSCLC),tumor-draining lymph nodes (TDLN),EDRIC,lymphopenia

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