The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing.

Pingping Hu,Yuwen Li,Wen Zhang, Rui Liu, Linya Peng,Ruirui Xu,Jinyuan Cai,Hui Yuan,Tiantong Feng,Anran Tian,Ming Yue,Jun Li,Wenting Li,Chuanlong Zhu

Mediators of inflammation（2023）

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摘要

, the spliceosome factor, is not IFN-inducible but is an IFN effector gene. EFTUD2 mediates IFN anti-HBV effect through regulation of gene splicing for certain ISGs, including , , and . EFTUD2 does not affect IFN receptors or canonical signal transduction components. Therefore, it can be concluded that EFTUD2 regulates ISGs using a novel, nonclassical mechanism.

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anti-hbv

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