PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells.

Yujing Zhao, Juan Wu, Shuai Guan,Ting Xue, Xiaolei Wei,Dawei Cao,Pengzhou Kong,Xinri Zhang

International journal of chronic obstructive pulmonary disease（2023）

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摘要

Based on these findings, we conclude that PIF1 inhibits the apoptosis of HPAECs by accelerating the autophagy pathway. Therefore, PIF1 plays a crucial role in HPAEC dysfunction in chronic hypoxia-induced PAH and may be a potential target for the treatment of PAH.

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chronic hypoxia induced apoptosis,pulmonary artery endothelial cells,autophagy,induced apoptosis

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