Community-acquired S. aureus infection in childhood: a multi-center

Background. The prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA) has been increasing worldwide. We aimed to investigate the prevalence of MRSA in community-acquired S. aureus infections, the risk factors for CA-MRSA infection and the clinical features of CA-MRSA.Methods. A multi-center study with prospective and retrospective sections was conducted. Patients & GE; 3 months old and & LE;18 years of age who were diagnosed with community-acquired S. aureus infections were included in this study and the patients' information were reviewed from the medical and microbiological database of the hospital. A standard question form about living conditions and exposure risk factors was administered to the parents of patients. The CA-MRSA infections were compared with the methicillin-susceptible S. aureus (CA-MSSA) infections in terms of the queried risk factors and clinical variables.Results. We identified 334 pediatric patients with S. aureus infection, 58 (17.4%) had an infection with CA-MRSA. The refugee rate was higher in the CA-MRSA group. There was no significant difference regarding the exposure risk. The treatment modalities and outcomes were similar.Conclusions. The study was not able to show reliable clinical variables or epidemiological risk factors except for being a refugee for CA-MRSA infections. Empirical antibiotic treatment should therefore be determined according to the local CA-MRSA prevalence in patients presenting with a possible staphylococcus infection.