Cancer-associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD-1 inhibitors and antiangiogenic agents in hepatocellular carcinoma.

Qiurui Chen,Xuejia Wang,Yichen Zheng,Ting Ye,Jing Liu,Jin-Quan Wang,Wen-Feng Zhang,Feng-Lin Wu,Huaben Bo,Hongwei Shao,Rongxin Zhang,Han Shen

Cancer（2023）

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摘要

This study not only revealed the TME characteristics of HCC with the difference in CAF abundance but also further confirmed that the combination therapy of PD-1 inhibitors and anti-angiogenic drugs may be more valuable for patients with high CAF abundance.

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关键词

angiogenesis, cancer-associated fibroblast, combination therapy, hepatocellular carcinoma, TACE, tumor immune microenvironment

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