Klotho Gene Expression Is Decreased in Peripheral Blood Mononuclear Cells in Patients with Alzheimer's Disease and Frontotemporal Dementia.

Federica Sorrentino,Chiara Fenoglio,Luca Sacchi,Maria Serpente,Andrea Arighi,Tiziana Carandini,Beatrice Arosio,Evelyn Ferri,Marina Arcaro,Caterina Visconte,Emanuela Rotondo,Elio Scarpini,Daniela Galimberti

Journal of Alzheimer's disease : JAD（2023）

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摘要

This is the first study investigating KL in FTD. We showed a decreased expression of the gene in AD and FTD, independent of the genotype, suggesting a role of Klotho in common steps during neurodegeneration.

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klotho gene expression,alzheimers,dementia,peripheral blood mononuclear cells,gene expression

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