Polyphenolic glycosides with unusual four-membered ring possessing anti-Parkinson's disease potential from black wolfberry
Phytochemistry(2023)
摘要
This work reports the isolation of seven undescribed polyphenolic glycosides (1-7) together with fourteen known compounds (8-21) from the fruit of Lycium ruthenicum Murray. The structures of the undescribed compounds were identified based on comprehensive spectroscopic methods including IR, HRESIMS, NMR and ECD, and chemical hydrolysis. Compounds 1-3 possess an unusual four-membered ring, while 11-15 were firstly isolated from this fruit. Interestingly, compounds 1-3 inhibited monoamine oxidase B with IC50 of 25.36 & PLUSMN; 0.44, 35.36 & PLUSMN; 0.54, and 25.12 & PLUSMN; 1.59 & mu;M, respectively, and showed significant neuroprotective effect on PC12 cells injured by 6-OHDA. Moreover, compound 1 improved the lifespan, dopamine level, climbing behavior, and olfactory ability of the PINK1B9 flies, a Drosophila model of Parkinson's disease. This work presents the first in vivo neuroprotective evidence of the small molecular compounds in L. ruthenicum Murray fruit, indicating its good potential as neuroprotectant.
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关键词
Lycium ruthenicum,Solanaceae,Black wolfberry,Polyphenolic glycosides,Ruthenines A -C,Anti-Parkinson's disease effect
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