Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment.

Jonathan M J Derry,Connor Burns,Jason P Frazier,Emily Beirne,Marc Grenley,Christopher C DuFort,Emily Killingbeck,Michael Leon,Claire Williams,Mark Gregory,Jeffrey Houlton,Daniel Clayburgh,Paul Swiecicki,Dennis Huszar,Allison Berger,Richard A Klinghoffer

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Pairing CIVO with spatial profiling enabled detailed investigation of response to subasumstat across a diverse sampling of native and intact TMEs. We demonstrate that drug mechanism of action can be directly evaluated in a spatially precise manner in the most translationally relevant setting: an in situ human tumor.

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