Past, present, and future of FGFR inhibitors in cholangiocarcinoma: from biological mechanisms to clinical applications.

Elisabeth Amadeo,Federico Rossari, Francesco Vitiello,Valentina Burgio,Mara Persano,Stefano Cascinu,Andrea Casadei-Gardini,Margherita Rimini

Expert review of clinical pharmacology（2023）

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摘要

As FGFR inhibitors may soon become the new alternative to standard chemotherapy in FGFR-mutated cholangiocarcinoma, accurate molecular testing and monitoring of acquired resistance mechanisms will be essential. The possible application of FGFR inhibitors in first-line treatment, as well as in combination to current standard treatments, remains the next step to be taken.

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cholangiocarcinoma,fgfr inhibitors

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