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It cuts both ways: A single-center retrospective review describing a three-way interaction between flucloxacillin, voriconazole and tacrolimus

Fay S. Burrows,Lilibeth M. Carlos,Jana Stojanova,Deborah J.E. Marriott

International journal of antimicrobial agents（2023）

Cited 0|Views8
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Abstract
•A significant three-way interaction was shown between flucloxacillin, tacrolimus and voriconazole.•When given in combination with flucloxacillin, voriconazole levels remain subtherapeutic despite voriconazole dose increases.•Tacrolimus dose requirements are considerably increased with concomitant flucloxacillin, but can be managed with close monitoring.
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Key words
Tacrolimus,Voriconazole,Flucloxacillin,CYP3A4,Drug-drug interaction,Therapeutic drug monitoring
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