Association of Apolipoprotein E4-related Microvascular Disease in the Alzheimer’s Disease Hippocampal CA1 Stratum Radiatum

Huaixing Wang,Zongxiu Zhang, Sorawit Sittirattanayeunyong,Jarin Hongpaisan

Neuroscience（2023）

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摘要

•Mild oxidative stress and VEGF reduction in capillaries of human AD hippocampus.•Strong oxidative stress, increased VEGF and wall cell number in AD + APOE4 arterioles.•Aβ decreases VEGF and human brain microvascular endothelial cell (HBMEC) density.•Aβ + ApoE4 increase strong oxidative stress, VEGF and cultured HBMEC cell density.

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alzheimers,microvascular disease

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