External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real World Data Sources.

Aparna C Swaminathan,Laurie D Snyder,Hwanhee Hong, Susanna R Stevens, Alexander S Long, Eric Yanchenko,Ying Qiu, Rong Liu, Hongtao Zhang,Aryeh Fischer,Leah Burns,Lisa M Wruck,Scott M Palmer

American journal of respiratory and critical care medicine（2023）

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摘要

IPF ECs generated from historical RCT placebo arms result in comparable primary treatment effects to that of the original clinical trial, while ECs from real-world data sources, including registry or EHR data, do not. RCT-ECs may serve as a potentially useful supplement to future IPF RCTs.

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关键词

idiopathic pulmonary fibrosis,pulmonary fibrosis,real-world

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