The Pathological Mechanism of Neuronal Autophagy-Lysosome Dysfunction After Ischemic Stroke
Cellular and molecular neurobiology(2023)
Abstract
The abnormal initiation of autophagy flux in neurons after ischemic stroke caused dysfunction of autophagy-lysosome, which not only led to autophagy flux blockage, but also resulted in autophagic death of neurons. However, the pathological mechanism of neuronal autophagy-lysosome dysfunction did not form a unified viewpoint until now. In this review, taking the autophagy lysosomal dysfunction of neurons as a starting point, we summarized the molecular mechanisms that led to neuronal autophagy lysosomal dysfunction after ischemic stroke, which would provide theoretical basis for the clinical treatment of ischemic stroke. Graphical Abstract
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Key words
Ischemic stroke,Autophagy flux,Neuronal autophagy-lysosome dysfunction
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