Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma.

Sho Sekiya,Junki Fukuda,Ryodai Yamamura,Takako Ooshio,Yusuke Satoh, Shinya Kosuge, Reo Sato,Kanako C Hatanaka,Yutaka Hatanaka,Tomoko Mitsuhashi,Toru Nakamura,Yoshihiro Matsuno,Satoshi Hirano,Masahiro Sonoshita

Cancer research（2023）

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摘要

Development of a Drosophila model mimicking genetic alterations in human pancreatic ductal adenocarcinoma provides a tool for genetic screening that identifies MEK and AURKB inhibition as a potential treatment strategy.

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