MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR.

Li Luo,Denghui Wei,Yihui Pan,Qiu-Xia Wang,Jian-Xiong Feng,Bing Yu,Tiebang Kang,Junhang Luo,Jiefeng Yang,Song Gao

Cancer communications (London, England)（2023）

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摘要

Our findings uncover an important non-canonical mitochondria-dependent pathway regulating EGFR signaling by the Rab21-MFN2-PTPRJ axis, which contributes to the development of novel therapeutic strategies for ccRCC.

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renal cell carcinoma progression,cell carcinoma

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