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Genome-wide CRISPR Screen Reveals RAB10 as a Synthetic Lethal Gene in Colorectal and Pancreatic Cancers Carrying SMAD4 Loss.

Hélène Erasimus,Vanessa Kolnik,Frédéric Lacroix,Sukhvinder Sidhu,Stéphane D'Agostino,Olivier Lemaitre,Alexandre Rohaut,Isabelle Sanchez,Gilbert Thill,Michel Didier,Laurent Debussche,Christophe Marcireau

Cancer research communications（2023）

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Abstract
This study identified and validated RAB10 as new synthetic lethal gene with SMAD4. This was achieved by conducting a whole-genome CRISPR screens in different colorectal and pancreatic cell lines. A future RAB10 inhibitors could correspond to a new therapeutic solution for patients with cancer with SMAD4 deletion.
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Key words
pancreatic cancers,crispr,rab10,smad4 loss,synthetic lethal gene,genome-wide
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