Nuclear Export Inhibitor Selinexor Enhances Oncolytic Myxoma Virus Therapy against Cancer.

Masmudur M Rahman,Fleur van Oosterom, Junior A Enow,Maksuda Hossain,Ami D Gutierrez-Jensen, Mackenzie Cashen,Anne Everts,Kenneth Lowe,Jacquelyn Kilbourne,Juliane Daggett-Vondras,Timothy L Karr,Grant McFadden

Cancer research communications（2023）

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摘要

We demonstrated that a combination of nuclear export inhibitor selinexor and oncolytic MYXV significantly enhanced viral replication, reduced cancer cell proliferation, reduced tumor burden, and enhanced the overall survival of animals. Thus, selinexor and oncolytic MYXV can be used as potential new anticancer therapy.

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inhibitor,cancer

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