Riboflavin protects against heart failure via SCAD-dependent DJ-1- Keap1-Nrf2 signaling pathway.

Qingping Xu,Yuhong Cao,Xiaoyi Zhong,Xue Qin,Jingyun Feng,Huan Peng,Yongshao Su,Zhichao Ma,Sigui Zhou

British journal of pharmacology（2023）

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摘要

Riboflavin exerts cardioprotective effects on heart failure by improving oxidative stress and cardiomyocyte apoptosis via adding FAD to stimulate SCAD, then activates the DJ-1-Keap1-Nrf2 signaling pathway.

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关键词

cell apoptosis, energy metabolism, heart failure, oxidative stress, riboflavin, short-chain acyl-CoA dehydrogenase, signalling pathway

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