BAG3 Overexpression Attenuates Ischemic Stroke Injury by Activating Autophagy and Inhibiting Apoptosis.

Xia Liu,Qinlian Ye,Zhengzheng Huang,Xiuping Li, Liping Zhang,Xuan Liu,Yun-Cheng Wu,Ulf Brockmeier,Dirk M Hermann,Ya-Chao Wang,Lijie Ren

Stroke（2023）

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摘要

Our findings indicate that BAG3 overexpression activates autophagy and inhibits apoptosis to prevent cerebral ischemia/reperfusion and hypoxia/reoxygenation injury, suggesting a potential therapeutic benefit of BAG3 expression in cerebral ischemia.

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关键词

apoptosis, autophagy, ischemia, middle cerebral artery

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