Independent Membrane Binding Properties of the Caspase Generated Fragments of the Beaded Filament Structural Protein 1 (BFSP1) Involves an Amphipathic Helix.

Miguel Jarrin,Alexia A Kalligeraki,Alice Uwineza,Chris S Cawood,Adrian P Brown,Edward N Ward,Khoa Le,Stefanie Freitag-Pohl,Ehmke Pohl,Bence Kiss,Antal Tapodi,Roy A Quinlan

Cells（2023）

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摘要

These data support the conclusion that C-terminal sequences of human BFSP1 distal to the caspase site at G433 have independent membrane binding properties via an adjacent amphipathic helix.

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关键词

lens, cataract, intermediate filaments, amphipathic helix, oligomerisation, intrinsically disordered domain, lipid binding, post-translational myristoylation, membrane scaffold

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