Risk factors for the development of second primary esophageal squamous-cell carcinoma after endoscopic resection for esophageal squamous-cell carcinoma according to genetic polymorphisms related to alcohol and nicotine metabolism.

Chikatoshi Katada,Tetsuji Yokoyama,Kanae Mure,Hisashi Doyama,Hiroyoshi Nakanishi,Yuichi Shimizu,Keiko Yamamoto,Yasuaki Furue,Masashi Tamaoki,Tomoyuki Koike,Yoshiro Kawahara,Hirofumi Kiyokawa,Maki Konno,Akira Yokoyama,Shinya Ohashi,Hideki Ishikawa, Akira Yokoyama,Manabu Muto

Japanese journal of clinical oncology（2023）

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摘要

Slow-metabolizing alcohol dehydrogenase 1B may be a significant risk factor for the development of second primary esophageal squamous-cell carcinoma. In addition, inactive aldehyde dehydrogenase 2 and poorly-metabolizing cytochrome P450 2A6 may be important factors.

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关键词

genetic polymorphisms,endoscopic resection,squamous-cell,squamous-cell

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