Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis.

Francisco Beraldi-Magalhaes,Suzanne L Parker,Cristina Sanches,Leandro Sousa Garcia,Brenda Karoline Souza Carvalho,Amanda Araujo Costa,Mariana Millan Fachi,Marcus Vinicius de Liz,Alexandra Brito de Souza,Izabella Picinin Safe,Roberto Pontarolo,Steven Wallis,Jeffrey Lipman,Jason A Roberts,Marcelo Cordeiro-Santos

Tropical medicine and infectious disease（2023）

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摘要

ICU patients had a lower clearance and volume of distribution for rifampin, isoniazid, pyrazinamide and ethambutol compared to the outpatient group. These may reflect changes to organ function, impeded absorption and distribution to the site of infection in ICU patients and have the potential to impact clinical outcomes.

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关键词

tuberculosis, antitubercular agents, rifampin, isoniazid, pyrazinamide, ethambutol, pharmacokinetics, biological availability, intensive care, critical care

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