Limited emergence of resistance to integrase strand transfer inhibitors (INSTIs) in ART-experienced participants failing dolutegravir-based antiretroviral therapy: a cross-sectional analysis of a Northeast Nigerian cohort.

Adam Abdullahi, Ibrahim Musa Kida, Umar Abdullahi Maina, Amina Husaini Ibrahim, James Mshelia, Haruna Wisso,Abdullahi Adamu, James Ezenwa Onyemata, Martin Edun,Haruna Yusuph,Sani H Aliyu,Man Charurat,Alash'le Abimiku,Lucie Abeler-Dorner,Christophe Fraser,David Bonsall,Steven A Kemp,Ravindra K Gupta

The Journal of antimicrobial chemotherapy(2023)

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摘要
This study found a low prevalence of resistance to dolutegravir; the data are therefore supportive of the continual rollout of dolutegravir as the primary first-line regimen for ART-naive participants and the preferred switch to second-line ART across the region. However, population-level, longer-term data collection on dolutegravir outcomes are required to further guide implementation and policy action across the region.
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关键词
antiretroviral therapy,transfer inhibitors,resistance,art-experienced,dolutegravir-based,cross-sectional
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