Role of Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Could It Be Considered a Predictor of Prognosis?

Ottavia De Simoni,Luca Dal Santo,Marco Scarpa,Giada Munari,Ylenia Camilla Spolverato,Antonio Scapinello,Sara Lonardi,Caterina Soldà,Francesca Bergamo,Alberto Fantin,Romeo Bardini,Pierluigi Pilati,Matteo Fassan,Mario Gruppo

Current oncology (Toronto, Ont.)（2023）

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摘要

Despite the retrospective nature and small sample size, our study showed that the high infiltration of CD8+ lymphocytes and low infiltration of FOXP3+ and TAMs iNOS+ are predictors of good prognosis. A preoperative assessment of these potential immune markers could be useful and determinant in the staging process and in PDAC management.

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pancreatic ductal adenocarcinoma,immune microenvironment,prognosis

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