Short-course subcutaneous treatment with PQ Grass strongly improves symptom and medication scores in grass allergy.

P J de Kam,S Zielen,J A Bernstein,U Berger,M Berger,M Cuevas, D Cypcar, A Fuhr-Horst, W A Greisner, M Jandl, S Laßmann,M Worm,J Matz, E Sher, C Smith, G C Steven,R Mösges,M H Shamji, L DuBuske, F Borghese,K Oluwayi, T Zwingers, M Seybold, O Armfield, M D Heath,S J Hewings,M F Kramer,M A Skinner

Allergy(2023)

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摘要
This trial demonstrated a clinically relevant and statistically significant efficacy response to PQ Grass. Unprecedented effect sizes were reached for grass allergy of up to ≈40% compared to placebo for CSMS after only six PQ Grass injections. Both PQ Grass regimens were considered equally safe and well-tolerated. Based on enhanced efficacy profile extended regime will be progressed to the pivotal Phase III trial.
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关键词
allergic rhinoconjunctivitis, grass pollen allergy, short-course treatment, subcutaneous immunotherapy
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