Dual targeting of apoptotic and signaling pathways in T-lineage acute lymphoblastic leukemia.

Caner Saygin, Giorgia Giordano, Kathryn Shimamoto,Bart Eisfelder,Anika Thomas-Toth,Girish Venkataraman,Vijayalakshmi Ananthanarayanan,Tiffaney L Vincent,Adam DuVall,Anand A Patel,Yi Chen,Fenlai Tan,Stephen P Anthony,Yu Chen,Yue Shen,Olatoyosi Odenike,David T Teachey,Barbara L Kee,James LaBelle,Wendy Stock

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

LCK and ACK1 signaling pathways are critical regulators of BH3 mimetic resistance in T-ALL. Combination of BH3 mimetics with tyrosine kinase inhibitors might be effective against relapsed T-ALL.

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关键词

lymphoblastic leukemia,signaling pathways,apoptotic,t-lineage

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