Validation of miRNAs as diagnostic and prognostic biomarkers, and possible therapeutic targets in medullary thyroid cancers.

Alberto Mondin,Loris Bertazza,Susi Barollo, Maria Chiara Pedron,Jacopo Manso,Ilaria Piva,Daniela Basso,Isabella Merante Boschin,Maurizio Iacobone,Raffaele Pezzani,Caterina Mian,Simona Censi

Frontiers in endocrinology（2023）

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摘要

Silencing miR-21, although not showing synergistic activity with TKIs (tyrosine kinase inhibitors), represents a potential alternative worth exploring as a therapeutic target for MTC.

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关键词

thyroid, medullary thyroid cancer, miR-21, PDCD4, miRNA silencing

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