New anti-diabetic drug Morus alba L. (Sangzhi) alkaloids (SZ-A) improves diabetic nephropathy through ameliorating inflammation and fibrosis in diabetic rats.

Caina Li, Quan Liu,Wenming Ji,Yaxin Fu, Hui Cao,Yi Huan,Lei Lei,Xuefeng Gao,Leilei Chen,Cunyu Feng,Lin Zhang,Pingping Li,Yuling Liu,Shuainan Liu,Zhufang Shen

Frontiers in medicine（2023）

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摘要

Repeated treatments with SZ-A significantly ameliorates DN by regulating systemic nitrosative stress, renal inflammation, and renal fibrosis partially through inhibition of the cytokine-NO and TGF-β1 signaling in ZDF rats, providing evidence for the additional application of SZ-A in clinical use for the treatment of DN.

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关键词

Morus alba L, (Sangzhi) alkaloids, diabetic nephropathy, oxidative stress, nitrosative stress, inflammation, renal fibrosis

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