MicroRNA let-7a mediates posttranscriptional inhibition of Nr4A1 and exacerbates cardiac allograft rejection.

Xiangchao Ding,Yifan Du, Bing Sun,Liang Liu,Sheng Le,Chuangyan Wu,Jiuling Chen,Xing Chen,Shanshan Chen,Jiahong Xia

Cellular signalling（2023）

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摘要

This study confirmed that let-7a is a potential target for interfering with Nr4A1 expression in CD4+ T cells and preventing the pathological progression of cardiac allograft rejection.

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关键词

Heart transplantation,Nr4A1,Let-7a,CD4+ T cells,Posttranscriptional regulation

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