Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization.

Sontoria D King,Swathi Veliginti,Martijn C G J Brouwers,Zhewen Ren,Wei Zheng,Veronica Wendy Setiawan,Lynne R Wilkens,Xiao-Ou Shu,Alan A Arslan,Laura E Beane Freeman,Paige M Bracci,Federico Canzian,Mengmeng Du,Steven J Gallinger,Graham G Giles,Phyllis J Goodman,Christopher A Haiman,Manolis Kogevinas,Charles Kooperberg,Loic Le Marchand,Rachel E Neale,Kala Visvanathan,Emily White,Demetrius Albanes,Gabriella Andreotti,Ana Babic,Sonja I Berndt,Lauren K Brais,Paul Brennan,Julie E Buring,Kari G Rabe,William R Bamlet,Stephen J Chanock,Charles S Fuchs,J Michael Gaziano,Edward L Giovannucci,Thilo Hackert,Manal M Hassan,Verena Katzke,Robert C Kurtz,I-Min Lee,Nuria Malats,Neil Murphy,Ann L Oberg,Irene Orlow,Miquel Porta,Francisco X Real,Nathaniel Rothman,Howard D Sesso,Debra T Silverman,Ian M Thompson,Jean Wactawski-Wende,Xiaoliang Wang,Nicolas Wentzensen,Herbert Yu,Anne Zeleniuch-Jacquotte,Kai Yu,Brian M Wolpin,Eric J Duell,Donghui Li,Rayjean J Hung,Sandra Perdomo,Marjorie L McCullough,Neal D Freedman,Alpa V Patel,Ulrike Peters,Elio Riboli,Malin Sund,Anne Tjønneland,Jun Zhong,Stephen K Van Den Eeden,Peter Kraft,Harvey A Risch,Laufey T Amundadottir,Alison P Klein, Rachael Z Stolzenberg-Solomon,Samuel O Antwi

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology（2023）

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摘要

Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and PC might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and PC.

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关键词

nonalcoholic fatty liver disease,nonalcoholic fatty liver,pancreatic cancer,genetic susceptibility

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