Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
Cureus(2023)
摘要
Vancomycin, a glycopeptide antibiotic, is widely used for Gram-positive cocci or bacilli bacteria-induced serious infections. Although considered safe and effective, it still causes adverse events. Vancomycininduced immune thrombocytopenia is a rarely reported adverse event, manifesting from asymptomatic thrombocytopenia to life-threatening bleeding. We underline a case of a 56-year-old male with a diabetic foot with an infected exudating purulent ulcer. He experienced a significant drop in platelet count after commencing vancomycin, and discontinuing vancomycin resulted in improved platelet count with positive vancomycin-induced anti-platelet antibodies. After ruling out other possible causes of thrombocytopenia, a presumptive diagnosis of vancomycin-induced thrombocytopenia was made.
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关键词
diabetic foot infections, immune-mediated thrombocytopenia, drug-induced immune thrombocytopenia, vancomycin-induced immune thrombocytopenia, vancomycin
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