Metabolic reprogramming through mitochondrial biogenesis drives adenosine anti-inflammatory effects: new mechanism controlling gingival fibroblast hyper-inflammatory state.

Nathalie Paladines,Shantiece Dawson, Weston Ryan,Rogelio Serrano-Lopez, Regina Messer,Yuqing Huo,Christopher W Cutler,Erivan S Ramos-Junior,Ana Carolina Morandini

Frontiers in immunology（2023）

引用 0|浏览3

暂无评分

摘要

Our findings reveal a key role for mitochondrial bioenergetics in regulation of CXCL8-mediated inflammation by HGF through the adenosine/AMPK/SIRT1/PGC-1α axis. Therapeutically targeting this pathway in gingival fibroblasts might be a promising future strategy to modulate stromal-mediated sustained hyper-inflammatory responses.

查看译文

关键词

fibroblasts, adenosine, mitochondrial biogenesis, inflammation, metabolism

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要