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Indoxyl sulfate inhibits muscle cell differentiation via Myf6/MRF4 and MYH2 downregulation.

Stanislas Bataille,Nathalie McKay,Laetitia Koppe,Alice Beau,Bérengère Benoit,Marc Bartoli,Nathalie Da Silva,Stéphane Poitevin,Julien Aniort,Rania Chermiti,Stéphane Burtey,Laetitia Dou

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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Abstract
In conclusion, IS inhibits Myf6/MRF4 and MYH2 expression during differentiation of muscle cells, which could lead to a defect in myotube structure. Through these new mechanisms, IS could participate in muscle atrophy observed in chronic kidney disease.
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Key words
chronic kidney disease, indoxyl sulfate, myogenesis, uremic toxin
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